Brain white matter microstructure associations with blood markers of the GSH redox cycle in schizophrenia.

ABSTRACT: In groups of patients suffering from schizophrenia (SZ), redox dysregulation was reported in both peripheral fluids and brain. It has been hypothesized that such dysregulation, including alterations of the glutathione (GSH) cycle could participate in the brain white matter (WM) abnormalities in SZ due to the oligodendrocytes' susceptibility to oxidative stress. In this study we aim to assess the differences between 82 schizophrenia patients (PT) and 86 healthy controls (HC) in GSH-redox peripheral blood markers: GSH peroxidase (GPx), reductase (GR) enzymatic activities and their ratio (GPx/GR-ratio), evaluating the hypotheses that alterations in the homeostasis of the systemic GSH cycle may be associated with pathological mechanisms in the brain WM in PT. To do so, we employ the advanced d

SUBMITTER: Pavan T 

PROVIDER: S-EPMC12495284 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature