Favorable outcomes of restrictive treatment indications in chronic lymphocytic leukemia: a retrospective analysis of Brazilian Registry of CLL.

ABSTRACT:

Background

The Brazilian Group of CLL (BGCLL) has proposed a more restrictive approach for treatment initiation compared to the International Workshop on Chronic Lymphocytic Leukemia (IWCLL) guidelines. Here, we report on the safety and efficacy of this strategy.

Methods

We performed a retrospective analysis of patients with CLL registered in the Brazilian CLL Registry between January 2009 and July 2023 who met the minimum data availability criteria for analysis. The BGCLL criteria employ stricter thresholds for cytopenias, defining them as hemoglobin levels below 9.5 g/dL or platelet counts below 50,000/mm³, as opposed to the IWCLL criteria of below 10 g/dL and below 100,000/mm³, respectively. Furthermore, the BGCLL criteria do not consider progressive

SUBMITTER: de Morais Marques F 

PROVIDER: S-EPMC12495331 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature