Antimicrobial applications of amphiphilic gold nanoparticles for antibiotic delivery.

ABSTRACT: Nanomedicine can offer novel strategies in the fight against antimicrobial resistance. Nano-sized drug carriers can be used to deliver antibiotics to their target to treat infections and some nanomaterials themselves have antimicrobial properties. Here, small amphiphilic gold nanoparticles with mixed ligand surfaces have been investigated for their potential use against bacterial infections in different settings. Owing to their unique surface properties, these nanoparticles are known to directly penetrate cell membranes, instead of entering cells by energy-dependent mechanisms of endocytosis, as observed for most nanomaterials. Therefore, we aimed to explore whether this capacity could be exploited to target and eliminate bacteria. To this end, different antibiotic-loaded small amphiphilic

SUBMITTER: Yedavally H 

PROVIDER: S-EPMC12495389 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature