Brain health operationalized as brain parenchymal fraction impacts stroke severity both in acute phase and 3 months post stroke.

ABSTRACT: Stroke lesion imaging alone is not sufficient to predict stroke severity and outcome at a clinically meaningful level, and non-lesional factors are to be defined to enable stroke prognosis and individually tailored therapy. While brain health concept is mainly discussed in the context of primary prevention of neurological diseases, quantitative parameters of brain health like brain parenchymal fraction (BPF) might be associated with better maintenance of function and compensation in (acute) brain pathology. We aimed to investigate whether BPF independently mediates neurological impairment and functional outcome after stroke. We retrospectively analysed patients with first-ever middle cerebral artery stroke. We used generalized linear models with gamma distribution and log link to model neu

SUBMITTER: Umarova RM 

PROVIDER: S-EPMC12495403 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature