The bi-phasic behaviour of grey matter networks after the first demyelinating attack.

ABSTRACT: Multiple sclerosis can be considered a network disease. Accumulating evidence recognizes the following importance of grey matter networks: they only require high-resolution anatomical scans for their extraction, they capture changes beyond detectable atrophy and their alteration is associated with disability progression and cognitive impairment. Therefore, it is crucial to understand their behaviours over the initial years of the disease. This observational longitudinal study aimed to investigate changes in grey matter networks after the first demyelinating attack, and how they correlate with brain damage, disability, and conversion to multiple sclerosis over 3-5 years. So far, in multiple sclerosis, network construction has only been based on cortical grey matter, neglecting a possible ro

SUBMITTER: Collorone S 

PROVIDER: S-EPMC12495409 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature