In vitro antiproliferative effects of green synthesized silver nanoparticles from Brassica carinata microgreens on DU-145 prostate cancer cells and In vivo safety assessment.

ABSTRACT:

Background

Prostate cancer ranks among the most lethal malignancies affecting men globally. Conventional therapeutic approaches for this disease encounter limitations due to adverse side effects and the emergence of drug resistance, making its management challenging. Green-synthesized silver nanoparticles (AgNPs) have emerged as an attractive alternative to address the shortcomings of existing anticancer treatments.

Objective

This study was undertaken to evaluate the anticancer potential and safety profile of BCM-AgNPs, focusing on DU-145 inhibition and sub-acute toxicity in Wistar rats.

Methods

Previously synthesized Brassica carinata microgreen silver nanoparticles (BCM-AgNPs) alongside Brassica carinata microgreen crude extract (BCME) were used. The antiproliferati

SUBMITTER: Somda D 

PROVIDER: S-EPMC12495471 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature