Adults with congenital heart disease experience worse short- and mid-term graft survival following heart transplantation from DCD donors: The early US experience.

ABSTRACT:

Background

Donation-after-circulatory-death (DCD) heart procurement is enlarging the donor pool, yet its safety in adults with congenital heart disease (ACHD) is uncertain. We compared early (90-day) and mid-term (3-year) graft outcomes after DCD versus donation-after-brain-death (DBD) heart transplantation in ACHD recipients.

Methods

Using the United Network for Organ Sharing registry (1 January 2018 - 1 April 2025), we identified adults (≥18 y) with ACHD undergoing isolated heart transplantation. Retransplants and multiorgan procedures were excluded. The primary endpoint was graft failure (death or retransplant). Survival was analysed with Kaplan-Meier curves, multivariable Cox models, and 1:1 nearest-neighbor propensity-score matching (caliper = 0.25 SD) adjusting for don

SUBMITTER: Berg AR 

PROVIDER: S-EPMC12495479 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature