History matters: Preventing severe allergic transfusion reactions.

ABSTRACT:

Objective

Prior studies have shown that pretransfusion medication is not effective in preventing allergic transfusion reactions (ATRs), but these studies did not consider the patient's history of ATR. This study evaluated whether pretransfusion antiallergy medications decrease the chance of ATRs in patients with a history of severe ATR.

Methods

This single-center, retrospective study investigated the effect of pretransfusion medications on preventing ATRs in patients with a history of at least 1 severe ATR between March 2018 and January 2024. Patient demographics as well as clinical and transfusion reaction data were collected from our electronic health record (EHR) system. Data were analyzed using SPSS (IBM Corp) and machine learning in Python, version 3.12.4.

Results

SUBMITTER: Wappler-Guzzetta EA 

PROVIDER: S-EPMC12495513 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature