Differential expression of MUC genes in endometrial and cervical tissues and tumors.

ABSTRACT:

Background

Mucin glycoprotein's are major components of mucus and are considered an important class of tumor associated antigens. The objective of this study was to investigate the expression of human MUC genes (MUC1, MUC2, MUC5B, MUC5AC and MUC8) in human endometrium and cervix, and to compare and quantitate the expression of MUC genes in normal and cancerous tissues.

Methods

Slot blot techniques were used to study the MUC gene expression and quantitation.

Results

Of the five-mucin genes studied, MUC1, MUC5B and MUC8 showed high expression levels in the normal and cancerous endometrial and cervical tissues, MUC2 and MUC5AC showed considerably lower expression. Statistically, higher levels of MUC1, MUC5B and MUC8 were observed in endometrial adenocarcinomas compared t

SUBMITTER: Hebbar V 

PROVIDER: S-EPMC1249559 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature