C-reactive protein-triglyceride glucose index predicts mortality in cardiovascular-kidney-metabolic syndrome stage 0-3: a prospective cohort study.

ABSTRACT:

Background

Cardiovascular-kidney-metabolic (CKM) syndrome is defined by the interplay of metabolic risk factors, chronic kidney disease, and cardiovascular disease. The C-reactive protein-triglyceride glucose index (CTI) is a composite biomarker that reflects both inflammation and insulin resistance, but whether it is associated with mortality in persons with early-stage CKM syndrome is unknown.

Methods

We analyzed data from the National Health and Nutrition Examination Survey from 1999 to 2010. We used multivariable Cox proportional-hazards models to assess the association between the CTI score and the risk of all-cause mortality and cardiovascular disease (CVD) mortality, with vital status ascertained through Linkage to the National Death Index through December 31, 2019.

SUBMITTER: Ying Q 

PROVIDER: S-EPMC12495607 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature