Survival risk stratification of 2021 WHO glioblastoma by MRI radiomics and biological exploration.

ABSTRACT:

Background

There is variability in overall survival among 2021 World Health Organization isocitrate dehydrogenase wild type glioblastoma (IDH-wt GBM) patients. The aim of the study was to develop a combined model for stratifying survival risk in IDH-wt GBM and explore the biological foundation.

Methods

A total of 369 IDH-wt GBM patients were retrospectively collected: 273 patients from three local hospitals (training set: n = 192, testing set: n = 81) and 96 patients from the TCIA database (validation set). Radiomics features from tumor and peritumoral edema in preoperative CE-T1WI and T2FLAIR were extracted. Univariate and least absolute shrinkage and selection operator Cox regression analyses selected significant radiomics features to construct radiomics model, while univa

SUBMITTER: Li Y 

PROVIDER: S-EPMC12495617 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature