Small left ventricular size as a predictor for incident type 2 diabetes: insights from the UK biobank cardiovascular magnetic resonance substudy.

ABSTRACT:

Background

Left ventricular (LV) concentric hypertrophy is common in diabetes patients, presenting as a relatively small LV size. However, studies have shown that a small LV size can also occur in prediabetic conditions without ventricular hypertrophy. We used data from the UK Biobank Cardiovascular Magnetic Resonance Substudy to assess whether a small LV size independently predicts incident type 2 diabetes.

Methods and results

Small LV size was defined using indexed left ventricular end-diastolic volume (iLVEDV) values (< 56 mL/m² for females and < 57 mL/m² for males). The risk of small LV size for incident type 2 diabetes was assessed using adjusted Cox proportional hazards models. The non-linear relationship between iLVEDV and diabetes risk was evaluated using restricted

SUBMITTER: Hu G 

PROVIDER: S-EPMC12495618 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature