Tissue-specific partitioning of flavonoids and phenolic acids coordinates bioactivities in Ormosia henryi Prain.

ABSTRACT: The accumulation patterns of bioactive compounds in Ormosia henryi Prain, a traditional Chinese medicinal herb, remain poorly understood, limiting its potential for development. In this study, LC-MS/MS-based untargeted metabolomics was used to profile metabolic patterns across six tissues: new leaves (NL), old leaves (OL), stem bark (SB), stem xylem (SX), root bark (RB), and root xylem (RX). Multivariate analyses (PCA, OPLS-DA) identified key differentially accumulated metabolites (DAMs), including 34 phenolic compounds: 29 flavonoids and 5 phenolic acids. The total flavonoid content (TFC) was highest in the old leaves, while the total phenolic content (TPC) peaked in the root bark. Tissue extracts demonstrated strong antioxidant and hypoglycemic activities, with the old leaves showing the

SUBMITTER: Zhang R 

PROVIDER: S-EPMC12495622 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature