Maternal glucose concentrations and DNA methylation of genes related to the PPAR signaling pathway in human placenta: insights for maternal glucose concentrations' effects on neonatal anthropometrics.

ABSTRACT:

Background

Accumulating evidence indicates that elevated maternal glucose concentrations during pregnancy are associated with adverse birth outcomes, but the mechanistic underpinnings remain unclear. This study aimed to evaluate the associations between maternal glucose concentrations and DNA methylation levels in genes related to the peroxisome proliferator-activated receptor (PPAR) signaling pathway in the human placenta and explore the potential mediating role of placental DNA methylation in the relationship between maternal glucose concentrations and neonatal anthropometric measures.

Methods

Maternal glucose concentrations were obtained from medical records, and neonatal anthropometric parameters were measured in 335 mother-infant pairs. DNA methylation levels of 14 gene

SUBMITTER: Li L 

PROVIDER: S-EPMC12495655 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature