Causal relationship between gut microbiota and pneumonia: a Mendelian randomization and retrospective case-control study.

ABSTRACT:

Background

The relationship between microbiota and the gut-lung axis has been extensively studied in both experimental and epidemiological contexts. However, it is still unclear whether the gut microbiome plays a causal role in the development of pneumonia.

Methods

Our study initially identified the genetic instruments in the gut microbiota GWAS across phylum, class, order, family, and genus levels. Pneumonia data were sourced from the open GWAS project of the Integrated Epidemiology Group (IEU). Mendelian randomization (MR) analysis employed several methods such as inverse variance weighting (IVW), weighted median, and MR-Egger, with Cochran's Q were calculated to assess heterogeneity via IVW and MR-Egger. Additionally, MR-PRESSO and MR-Egger intercepts were utilized to mit

SUBMITTER: Huang P 

PROVIDER: S-EPMC12495658 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature