Comparison of theoretical proteomes: identification of COGs with conserved and variable pI within the multimodal pI distribution.

ABSTRACT:

Background

Theoretical proteome analysis, generated by plotting theoretical isoelectric points (pI) against molecular masses of all proteins encoded by the genome show a multimodal distribution for pI. This multimodal distribution is an effect of allowed combinations of the charged amino acids, and not due to evolutionary causes. The variation in this distribution can be correlated to the organisms ecological niche. Contributions to this variation maybe mapped to individual proteins by studying the variation in pI of orthologs across microorganism genomes.

Results

The distribution of ortholog pI values showed trimodal distributions for all prokaryotic genomes analyzed, similar to whole proteome plots. Pairwise analysis of pI variation show that a few COGs are conserved withi

SUBMITTER: Nandi S 

PROVIDER: S-EPMC1249567 | biostudies-literature | 2005 Sep

REPOSITORIES: biostudies-literature