Multi-omics and network pharmacology approaches reveal the mechanism of action of KeKe tablet against post-infectious cough.

ABSTRACT:

Background

Post-infectious cough (PIC) refers to a persistent cough lasting longer than three consecutive weeks following an infection, despite the resolution of other symptoms and normal examination results. This common respiratory disorder significantly impacts patients' quality of life due to the ongoing coughing. The Keke tablet (KKP), an herbal medicine preparation, is frequently used as an over-the-counter (OTC) treatment for respiratory conditions. However, the mechanisms underlying KKP's efficacy are not yet fully understood.

Objective

This study aims to evaluate the therapeutic effects of KKP in treating PIC and to explore its potential mechanisms of action.

Methods

Rat models of post-infectious cough (PIC) were established through exposure to cigarette smoke

SUBMITTER: Su M 

PROVIDER: S-EPMC12495694 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature