Hyperbaric oxygen therapy for late radiation tissue toxicity injury after head and neck cancer: a systematic review of the literature.

ABSTRACT:

Background

Head and neck cancer (HNC), most of which are squamous cell carcinomas, is the seventh most common cancer worldwide. Radiotherapy is a standard treatment for HNC but may lead to late complications and severe complications like osteoradionecrosis (ORN) and impaired wound healing due to tissue hypoxia. Hyperbaric oxygen therapy (HBOT) has shown promise in ameliorating these late radiation effects. The purpose of this review is to summarize the extent of the literature on the effectiveness of HBOT in the treatment of late radiation tissue toxicity injuries (LRTTI) specifically in HNC patients.

Methods/material and methods

A systematic literature search was performed using PubMed, Embase, and the Cochrane Library on August 12, 2024, including studies published between

SUBMITTER: El Hadji S 

PROVIDER: S-EPMC12495706 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature