The safety and efficacy of appendectomy, endoscopic retrograde appendicitis therapy, and antibiotic treatment for acute uncomplicated appendicitis: a systematic review and network meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Appendicitis, as a prevalent acute abdominal condition in general surgery, has established a comprehensive diagnostic and therapeutic framework. However, significant academic debate persists regarding the optimal treatment strategy. With advancements in minimally invasive techniques, endoscopic retrograde appendicitis therapy (ERAT) has emerged as an innovative therapeutic approach, providing new options for clinical decision-making. This study employed network meta-analysis to systematically evaluate and compare the clinical efficacy and safety profiles of three treatment modalities: conventional appendectomy, the ERAT, and pharmacological conservative therapy.

Methods

We systematically reviewed randomized controlled trials (RCTs) published through 2024 that eval

SUBMITTER: Wang J 

PROVIDER: S-EPMC12495716 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature