Comprehensive identification of immune-related biomarkers and therapeutic targets in preeclampsia: integrative bioinformatics and experimental validation.

ABSTRACT:

Background

Preeclampsia (PE) is a serious hypertensive complication during pregnancy characterized by immune dysregulation and vascular dysfunction, however, the precise molecular mechanisms and effective therapeutic strategies remain unclear. This study focused on identifying immune-related differentially expressed genes (IRDEGs) in PE, investigate their biological significance and regulatory networks, and establish robust diagnostic models through integrated bioinformatics and experimental analyses.

Methods

Gene expression data from the GSE75010 dataset were analyzed utilizing the R-based "limma" package to determine differentially expressed genes (DEGs), which were intersected with immune-related genes (IRGs) to obtain IRDEGs. Functional enrichment was assessed using Gene

SUBMITTER: Wu X 

PROVIDER: S-EPMC12495723 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature