Impact of iron deficiency on therapeutic outcomes in colorectal cancer patients: a single-center cohort study.

ABSTRACT:

Background

Iron deficiency (ID) exhibits strikingly high prevalence in colorectal cancer (CRC), yet its prognostic implications remain insufficiently characterized. This study aimed to evaluate the association between pre-treatment ID status and therapeutic outcomes in patients undergoing standardized treatment protocols for CRC.

Methods

A retrospective cohort of 1003 CRC patients was analyzed to assess the prevalence of ID and its correlations with clinicopathologic features, postoperative recovery, neoadjuvant therapy response, and iron metabolism and ferroptosis-related gene expression. The association of ID with clinicopathologic data, laboratory parameters, and treatment patient outcome was analyzed using logistic regression. Prussian blue staining was used to assess ir

SUBMITTER: Luo Y 

PROVIDER: S-EPMC12495790 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature