CircRNA-14052 promotes breast cancer progression via miR-214-3p/IKBKB pathway.

ABSTRACT:

Objectives

Circular RNAs play crucial regulatory roles in the progression of human diseases. This study aimed to investigate the functional mechanism of circRNA-14,052 in breast cancer progression.

Methods

The biological functions of circRNA-14,052 were assessed using CCK-8, wound healing, flow cytometry assays. The ceRNA regulatory network of circRNA-14,052-miR-214-3p- IKBKB was validated by luciferase reporter assay.

Results

The levels of circRNA-14,052 were notably elevated, but the levels of miR-214-3p were markedly reduced in breast cancer tissues compared to adjacent non-cancerous tissues. Downregulation of circRNA-14,052 or overexpression of miR-214-3p reduced MCF-7 cell proliferation and triggered cell apoptosis. Mechanically, circRNA-14,052 could elevate IKBK

SUBMITTER: Li D 

PROVIDER: S-EPMC12495841 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature