In-utero exposure to maternal diabetes and DNA methylation alterations in the Next Generation birth cohort.

ABSTRACT:

Introduction

The incidence of type 2 diabetes (T2D) in youth is increasing and in-utero exposure to maternal diabetes is a known risk factor, with higher risk associated with pregestational T2D exposure compared to gestational diabetes mellitus (GDM) exposure. We hypothesize this differential risk is reflected in DNA methylation (DNAm) changes induced by differential timing of in-utero exposure to maternal diabetes, and that exposure to diabetes throughout pregnancy (T2D) compared to exposure later in development (GDM), induces different DNAm signatures and different T2D risk to offspring. This study presents an epigenome-wide investigation of DNAm alterations associated with in-utero exposure to either maternal pregestational T2D or GDM, to determine if the timing of prenatal diab

SUBMITTER: Salama OE 

PROVIDER: S-EPMC12495848 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature