Swab-based anal cancer screening in men living with HIV: Projected outcomes for different screening algorithms.

ABSTRACT: Screening for and treatment of anal cancer precursor lesions, high-grade squamous intraepithelial lesions (HSIL), can prevent anal cancer. Recent guidelines set by the International Anal Neoplasia Society recommend digital anal rectal examination (DARE) and anal swab-based screening of high-risk individuals by means of high-risk (hr)HPV testing or cytology. We used our biobank containing data of more than 600 high-resolution anoscopy (HRA) screened participants (94% men with HIV) to compare the possible screening algorithms. We selected the 298 screening participants in whom anal swabs were successfully tested for hrHPV and cytology, parallel to HRA screening (DARE followed by complete visual inspection by HRA). We compared outcomes of several strategies (single-test, co-testing, two-step

SUBMITTER: Rozemeijer K 

PROVIDER: S-EPMC12496001 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature