Obstacles, Opportunities, and Ethical Considerations for Genomic Investigations of Individuals Continuously Hospitalized with Treatment-resistant Schizophrenia.

ABSTRACT:

Background and hypothesis

The overarching objective when studying schizophrenia is the development of generalizable knowledge that improves patient health and/or increases our comprehension of their illness. To fully achieve this objective, investigations need to reflect the full range of individual variation found within this heterogeneous population. But individuals committed to state psychiatric institutions have been routinely excluded from research because of concerns that they may not be able to understand or provide adequately informed consent. While reasonable, we believe this approach has enabled policies that support implicit bias, contribute to health care disparities, and limit our knowledge of disease mechanisms and treatment.

Study design

This article pr

SUBMITTER: Josiassen RC 

PROVIDER: S-EPMC12496010 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature