Gender differences in depression, anxiety, and quality of life in Parkinson's disease before and after deep brain stimulation surgery: a multicentre cohort study.

ABSTRACT:

Background

Disproportionately fewer females with Parkinson's disease (PD) undergo deep brain stimulation surgery (DBS). Some data show worse depression, anxiety, and quality of life (QOL) in females with PD. Investigations into these gender disparities, or the effect of DBS on these non-motor symptoms, remain limited.

Methods

61 PD patients across seven UK DBS centres were recruited for the Clinical Response of Impulsive behaviours to deep brain Stimulation in PD (CRISP) prospective cohort study. Questionnaires measured primary outcomes of depression (Patient Health Questionnaire-9), anxiety (Generalised Anxiety Disorder-7) and QOL (Parkinson's Disease Questionnaire-39) before and 6 months after bilateral subthalamic nucleus DBS, and secondary outcomes of predictors of posto

SUBMITTER: Abbott MG 

PROVIDER: S-EPMC12496053 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature