Abscopal effects in patients with malignant melanoma treated with radiotherapy and immune checkpoint inhibition: analysis of a large observational multicenter study.

ABSTRACT:

Background

Abscopal effect (AbE), the regression of non-irradiated metastatic lesions (NILs) following radiotherapy (RT), is relevant in patients with malignant melanoma (MM) with progressive disease (PD) under immune checkpoint inhibition (ICI) as resistance to immunotherapy. In the "ARTIC" trial, we assessed the incidence of AbE in patients with progressive MM by evaluating the effect of RT on NILs.

Methods

ARTIC (Abscopal effects in metastasized cancer patients treated with RadioTherapy and Immune Checkpoint inhibition) (ARO (Arbeitsgemeinschaft Radiologische Onkologie) 2022-10, DRKS00032390) retrospectively screened clinical records of patients with stage IV MM with PD under ICI. Patients received RT for metastases and had ≥1 NIL outsid

SUBMITTER: Ferdinandus S 

PROVIDER: S-EPMC12496099 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature