Association between gout, hyperuricaemia and Parkinson's disease risk: a cohort study in western Sweden (2001-2017).

ABSTRACT:

Objectives

Neurodegenerative diseases including Parkinson's disease (PD) have been found to be associated with gout and hyperuricaemia in multiple studies but with conflicting results. We set out to determine the incidence and relative risk of PD in all gout individuals in western Sweden from 2001 to 2016 compared with controls. Blood urate levels in gout patients with and without incident PD were compared.

Methods

All individuals with a gout diagnosis between 2001 and 2016 were identified and matched to population non-gout controls; individuals with prevalent PD were excluded. PD incidence rates were compared between cases and controls. The effect of gout on the risk of PD was calculated using Cox regression. The plasma urate level was identified for all gout cases.

Resu

SUBMITTER: Dehlin M 

PROVIDER: S-EPMC12496132 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature