Long-term safety of mid-urethral sling for stress urinary incontinence in women: an emulated trial using French national health data system.

ABSTRACT:

Background

Mid-urethral sling (MUS) is the most-indicated therapy for treating stress urinary incontinence (SUI) in women. However, serious long-term side effects have escaped post-marketing studies. We aimed to compare two different MUS types, tension-free vaginal tape (TVT) and trans-obturator tape (TOT), in terms of incidence of MUS removal or section after implantation.

Methods

We emulated a hypothetical target trial using French national healthcare data (SNDS) and included women who had undergone a first MUS implantation from 2011 to 2018 (Health Data Hub registration no. T16166982020061). The primary outcome was the cumulative incidence of MUS removal or section. Secondary outcomes were the cumulative incidence of MUS removal and section, hospitalization for urinary re

SUBMITTER: Guillot-Tantay C 

PROVIDER: S-EPMC12496164 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature