Intrathecal monovalent fragments from two human monoclonal antibodies block tetanus neurotoxin in rodents.

ABSTRACT: Tetanus is a life-threatening disease characterized by spastic paralysis caused by Tetanus Neurotoxin (TeNT). Spasticity arises after TeNT is retro-transported inside peripheral nerves and released into spinal interstitial fluids, where it intoxicates inhibitory interneurons, blocking GABA/Glycine release. The only approved treatment, intramuscular antisera, is ineffective once TeNT has entered peripheral nerves. Here, we show that the intrathecal injection of F(ab)₁ fragments from TT104 and TT110-two potent TeNT-neutralizing human monoclonal antibodies-intercepts the TeNT molecules escaping peripheral neutralization by intramuscular antisera, enhancing protection from tetanus in rodents. F(abs)₁ achieve efficacy at markedly lower quantities than those tested in previ

SUBMITTER: Fabris F 

PROVIDER: S-EPMC12496176 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature