Skeletal Muscle Mass Measured Noninvasively by D₃-Creatine Dilution in Children and Term Infants.

ABSTRACT:

Objective

To measure the longitudinal changes in body composition including muscle mass (MM), total body water (TBW), and body fat in term infants and children using the D₃Creatine (D₃Cr) dilution method combined with ²H₂O.

Study design

A total of 36 term infants were enrolled and measured at baseline and after 6 and 12 months. In addition, 30 boys (ages 4-12 years) and 31 girls (ages 4-10 years) were enrolled. A single dose of D₃Cr in 20% ²H₂O was administered orally using a syringe. Saliva and urine samples were used to determine ²H₂O and D₃Cr D₃creatinine enrichments for determination of TBW (fat-free mass [FFM]) and MM, respectively.

Results

Bod

SUBMITTER: Shankaran M 

PROVIDER: S-EPMC12496178 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature