The noncoding circular RNA <i>circHomer1</i> regulates synaptic development and experience-dependent plasticity in the mouse visual cortex.

ABSTRACT: Circular RNAs (circRNAs) are closed-loop, single-stranded RNAs particularly enriched in the brain. Despite this enrichment, and evidence showing that synaptic development and plasticity alter their expression in vitro, circRNA regulation by and function in experience-dependent plasticity in vivo remain unexplored. Through transcriptome-wide analysis in juvenile mouse primary visual cortex (V1) following monocular deprivation (MD), we identified that the circular and the activity-dependent mRNA forms of the Homer1 gene, circHomer1 and Homer1a, respectively, showed opposing changes in expression following 3-day MD: circHomer1 increased while Homer1a decreased. Knockdown of circHomer1 delayed the depression of closed-eye responses normal

SUBMITTER: Jenks KR 

PROVIDER: S-EPMC12496186 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature