Monocytes from people with Familial Hypercholesterolaemia are inflammatory, despite statin-treatment.

ABSTRACT:

Background and aims

Familial Hypercholesterolaemia (FH) is characterised by high cholesterol and premature cardiovascular disease. While hypercholesterolaemia and inflammation are both key drivers in the formation of atherosclerotic plaques, inflammation remains understudied in FH. Inflammatory (M1) macrophages contribute to plaque destabilisation and macrophage precursors, monocytes, can be skewed towards an inflammatory state. Aims: Determine; whether monocytes of FH individuals are inflammatory, if they readily form inflammatory macrophages, and whether this remains so in statin-treated individuals.

Methods

Blood samples were collected from people with FH (statin-treated and untreated) and healthy controls. Lipid profile was obtained and monocyte inflammatory marker expre

SUBMITTER: Williams H 

PROVIDER: S-EPMC12496229 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature