Integrated multi-omics analysis identifies TPX2 as a potential prognostic and immunological biomarker in hepatocellular carcinoma.

ABSTRACT:

Background and aims

Hepatocellular carcinoma (HCC) is a leading cause of cancer-related mortality worldwide, characterized by aggressive behavior, limited therapeutic efficacy, and poor patient outcomes. TPX2, a microtubule-associated protein essential for mitotic spindle formation, has been associated with tumorigenesis in various cancers. However, its functional significance in shaping the immune landscape and influencing treatment sensitivity in HCC remains insufficiently elucidated.

Methods

We conducted an integrated multi-omics analysis using transcriptomic (TCGA, GTEx, GEO), proteomic (CPTAC), and pharmacogenomic (GDSC, PRISM, CTRP) datasets to assess TPX2 expression patterns in HCC. We performed differential expression analysis, survival analysis, Cox regression, and

SUBMITTER: Peng H 

PROVIDER: S-EPMC12496236 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature