Refinement of day 28 treatment response criteria for acute GVHD: a collaboration study of the JSTCT and MAGIC.

ABSTRACT:

Abstract

Overall response (OR) that combines complete (CR) and partial responses (PR) is the conventional end point for acute graft-versus-host disease (GVHD) trials. Because PR includes heterogeneous clinical presentations, reclassifying PR could produce a better end point. Patients in the primary treatment cohort from the Japanese Society for Transplantation and Cellular Therapy (JSTCT) were randomly divided into training and validation sets. In the training set, a classification and regression tree algorithm generated day 28 refined response (RR) criteria based on symptoms at treatment and day 28. We then evaluated RR for primary and second-line treatments, using the area under the receiver operating characteristic curve (AUC) and negative predictive value (NPV) for 6-month nonr

SUBMITTER: Akahoshi Y 

PROVIDER: S-EPMC12496244 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature