KRAS mutations promote PD-L1-mediated immune escape by ETV4 in lung adenocarcinoma.

ABSTRACT: KRAS mutations are frequently associated with immune escape in lung adenocarcinoma. The aim of this research is to investigate the molecular mechanism underlying the KRAS-driven upregulation of PD-L1 and its role in immune escape.

Methods

Transcriptomic data combined with data from the GEO database and immunohistochemistry were used to analyze the expression of PD-L1 in KRAS-mutant tissues. Functional experiments were performed using KRAS knockdown and MEK-ERK signaling pathway inhibitors to reveal the major signaling pathways by which KRAS mutations regulate PD-L1 expression. The key transcription factors regulating PD-L1 expression were identified through weighted gene coexpression network analysis (WGCNA) combined with dataset screening, and the binding sites of the key transcrip

SUBMITTER: Jia D 

PROVIDER: S-EPMC12496248 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature