Risk stratification of high-risk muscle invasive upper urinary tract urothelial carcinoma: multi-institutional study.

ABSTRACT:

Purpose

This study aimed to analyze a large multi-institutional UTUC database to identify prognostic factors in patients with organ-confined and non-organ-confined disease, and to further stratify pT2 patients using a nomogram to identify high-risk subgroups who may benefit from adjuvant therapy.

Methods

The records of patients diagnosed with UCTC who underwent nephroureterectomy from 1988 to 2022 at 15 hospitals in Taiwan were retrospectively reviewed. The outcomes evaluated were overall survival (OS), cancer-specific survival (CSS), disease-free survival (DFS), and bladder recurrence-free survival (BRFS) after nephroureterectomy.

Results

A total of 2635 patients were included: 1935 with organ-confined (pTis/pTa/pT1/pT2 stage) disease, and 700 with non-organ confined

SUBMITTER: Luo HL 

PROVIDER: S-EPMC12496281 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature