Creeping fat is associated with transmural healing in patients with Crohn's disease receiving ustekinumab.

ABSTRACT:

Objectives

We investigated whether body composition parameters assessed on baseline computed tomography enterography (CTE) could predict transmural healing (TH) in patients with Crohn's disease (CD) receiving Ustekinumab (UST).

Materials and methods

Adult patients with active CD treated with standard UST from August 2020 to August 2022 were enrolled. Body composition, including creeping fat (CF, mesenteric creeping fat index (MCFI) and fibrofatty proliferation score), skeletal muscle, visceral adipose, and subcutaneous adipose-related parameters were assessed on baseline CTE. Cox regression analysis was performed to identify independent predictors of TH.

Results

This study included 113 patients, and TH occurred in 26 (23. 0%) patients. The results of the univariable a

SUBMITTER: Zhang F 

PROVIDER: S-EPMC12496395 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature