Personalizing colorectal Cancer treatment: Chemotherapy drug testing with patient-derived tumor cell clusters.

ABSTRACT:

Background

Due to the heterogeneity of colorectal cancer (CRC), models that can predict the chemotherapy response are needed to facilitate personalized treatment.

Aim

To construct patient-derived tumor-like cell cluster (PTC) models in vitro drug sensitivity screening for CRC personalized chemotherapy.

Methods

We collected 140 CRC tissues via surgical resection in three Chinese hospitals and establish PTC models which is highly similar to the original tumor tissue. The sensitivity to various chemotherapy drugs was assessed in these PTC models. We recorded the PTC model cultivation process and patients' clinical data and assessed the concordance between in vitro drug sensitivity and clinical outcomes.

Results

PTC models were successfully established from 124 spe

SUBMITTER: Qiu X 

PROVIDER: S-EPMC12496415 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature