In vitro fertilization with preimplantation genetic testing compared with donor sperm and natural conception among male Robertsonian translocation carriers: a cost-effectiveness analysis.

ABSTRACT:

Objective

To investigate the cost-effectiveness of reproductive strategies for male carriers of Robertsonian translocations.

Design

We designed a model to compare the outcomes and costs of three strategies: in vitro fertilization with preimplantation genetic testing for structural rearrangements (IVF PGT-SR), frozen donor sperm intrauterine insemination, and natural conception. The model was built using a Markov process to simulate one year of clinical care (up to 3 cycles of IVF, 6 intrauterine inseminations, or 12 attempts at natural conception), incorporating delays between cycles for adverse outcomes.

Subjects

Theoretical cohort of 2,751, an estimate of men aged 15-49 diagnosed with subfertility or nonsurgical sterility that are carriers of the most common Roberts

SUBMITTER: Melville SJF 

PROVIDER: S-EPMC12496424 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature