Comparable Clinical and Embryological Outcomes in Luteal and Follicular Phase Controlled Ovarian Hyperstimulation: A Retrospective Cohort Study.

ABSTRACT:

Objective

To study whether luteal phase stimulation provides clinical and embryological outcomes comparable to follicular phase stimulation in controlled ovarian hyperstimulation cycles.

Design

Retrospective cohort study.

Subjects

A total of 12,442 patients undergoing 18,062 in vitro fertilization cycles between January 1, 2018, and December 21, 2021, across 6 assisted reproductive technology centers within a large US fertility network.

Exposure

Patients underwent controlled ovarian hyperstimulation using either follicular phase or luteal phase initiation. Cycles involving fresh transfers, day 3 transfers, or poor endometrial receptivity were excluded.

Main outcome measures

The primary outcomes were clinical pregnancy rates and cumulative live birth rate

SUBMITTER: Gao F 

PROVIDER: S-EPMC12496433 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature