Do children born after embryo vitrification differ from siblings born after fresh embryo transfer?

ABSTRACT:

Objective

To assess neonatal outcomes in siblings born after frozen embryo transfer (FET) in comparison with siblings born after fresh embryo transfer.

Design

Prospective cohort study. Linear mixed models and generalized linear mixed models were used to study the association between outcomes after FET vs. fresh embryo transfer, considering the correlation of observations from siblings and controlling for treatment and maternal characteristics. Subgroup analysis according to the day of fresh embryo transfer and according to the FET protocol was also performed.

Subjects

Sibling pairs of singletons born to mothers who had both fresh and vitrified embryos transferred between 2008 and 2021, irrespective of the order (fresh-frozen or frozen-fresh) from a single center were

SUBMITTER: Belva F 

PROVIDER: S-EPMC12496438 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature