Inhibition of P2X7 receptor in satellite glial cells contributes to electroacupuncture's analgesia in rats with CFA-induced inflammatory pain.

ABSTRACT:

Background

Accumulating evidence highlights the anti-inflammatory and analgesic effects of electroacupuncture (EA), yet the underlying mechanisms remain poorly understood. The P2X7 purinergic receptor (P2X7R), located in the peripheral and central nervous systems, has been implicated in the development of chronic inflammatory pain. Inhibition of P2X7R expression has been associated with the analgesic effects of EA. Within the dorsal root ganglia, P2X7R is exclusively expressed in satellite glial cells (SGCs), but its role in the anti-inflammatory effects of EA remains to be elucidated.

Methods

A chronic inflammatory pain model was established in rats via intraplantar injection of Complete Freund's Adjuvant (CFA). Western blotting, immunostaining, behavioral assay, pharmacolo

SUBMITTER: Wu Y 

PROVIDER: S-EPMC12497349 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature