Barriers to cervical cancer prevention and triage strategies: a study of knowledge, attitudes, and p16/Ki-67 dual-staining utility among high-risk women in Tuoli and Fuyun counties, Xinjiang.

ABSTRACT:

Objective

To investigate cervical cancer screening knowledge, attitudes, and practices among high-risk women in remote western China, and to identify socioeconomic and systemic barriers influencing screening participation. Additionally, to evaluate the comparative effectiveness of p16 staining versus p16/Ki-67 dual-staining immunocytochemistry in triaging women with cytological abnormalities or HPV-positive results, aiming to reduce unnecessary colposcopy referrals in resource-limited settings.

Methods

This cross-sectional study enrolled 260 women (aged 20-65 years) with cytological abnormalities or HPV-positive results from two remote counties in Xinjiang Province (January-December 2023). Participants completed structured questionnaires assessing cervical cancer knowledge,

SUBMITTER: Tali H 

PROVIDER: S-EPMC12497396 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature