A gelatin sponge-hemocoagulase sealant for preventing tumor biopsy complications: a dual mechanical and pharmacological barrier.

ABSTRACT:

Background

A CT-guided tumor biopsies carry substantial risks, with literature-reported complication rates reaching 43% and pulmonary biopsy pneumothorax intervention rates as high as 22.1%. This study validates a novel needle tract sealing technique combining absorbable gelatin sponge (mechanical occlusion) with Agkistrodon acutus-derived hemocoagulase (local coagulation), leveraging synergistic physico-chemical mechanisms.

Methods

This prospective single-arm cohort enrolled 87 consecutive patients undergoing CT-guided biopsies (Feb 2023-Jun 2025). The core technique involved retrograde injection during needle withdrawal of 1mm³ gelatin sponge particles suspended in 0.5KU hemocoagulase (total volume: 1.5ml), with stratified dosing for D-dimer levels >2mg/L. Primary outcomes

SUBMITTER: Chen X 

PROVIDER: S-EPMC12497518 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature