The Optimal Dose, Efficacy and Safety of Tranexamic Acid on Hemorrhage Control for High Tibial Osteotomy: A Network Meta-Analysis.

ABSTRACT:

Objective

This systematic review and network meta-analysis was performed to explore the optimal dose, efficacy, and safety of tranexamic acid (TXA) treatments versus placebo for high tibial osteotomy (HTO) patients.

Methods

PubMed, Embase, Cochrane Library, Wanfang database, and Chinese National Knowledge Infrastructure (CNKI) databases were searched for the randomized controlled trials (RCTs) meeting prespecified inclusion criteria up to March 2024. Interventions included TXA and placebo treatments. The outcomes included total blood loss, drainage, hemoglobin drop, the occurrence of deep venous thrombosis (DVT) and hematoma. Traditional meta-analysis and network meta-analysis were performed by Stata and R software, respectively.

Results

Traditional meta-analysis reve

SUBMITTER: Zhao Z 

PROVIDER: S-EPMC12497536 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature