Association between genetic mutations in lung adenocarcinoma and adult body mass index: a retrospective cohort study.

ABSTRACT:

Background

The impact of obesity on gene mutations in lung adenocarcinoma(ADC) remains unclear. This study investigates the association between Body Mass Index(BMI) and the gene mutation in ADC.

Methods

This study investigated the relationship between BMI and ADC gene mutation. Logistic regression model was used to verify the association between BMI and ADC gene mutations. Threshold effect analysis is used to distinguish between linear and nonlinear. Subgroup analyses rigorously assessed demographic variations, significantly strengthening the study's credibility. Concurrently, the ROC curves were utilized to predict ADC gene mutation.

Results

In our study, average ages of 66.00 vs. 65.00 were observed for ADC with gene mutation and ADC without gene mutation, re

SUBMITTER: Wu YQ 

PROVIDER: S-EPMC12497579 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature