Multi-omic analysis identifies erythroid cells as the major population in mouse placentas expressing genes for antigen presentation in MHC class II, chemokines, and antibacterial immune response.

ABSTRACT:

Introduction

Pregnancy is a complex process that requires a tightly regulated immune environment to support fetal development and protect against infections. The main barrier between fetus and mother is a specialized organ, the placenta, where the role of specific immune cell populations remains incompletely understood.

Methods

In this work, we used spatial transcriptomics at E12.5 to characterize immune and non-immune cell heterogeneity and spatial organization in the mouse placenta. In addition, we performed murine placental mononuclear cell flow cytometry proteomics, murine placental erythroid cell NanoString bulk transcriptomics, and murine placental erythroid cell LegendPlex secretomics at E12.5 and E19.5 to further analyze the immune landscape in the mouse placenta. We

SUBMITTER: Perik-Zavodskaia O 

PROVIDER: S-EPMC12497581 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature