Impact of phthalate exposure on gestational diabetes mellitus: a systematic review.

ABSTRACT:

Background

Gestational Diabetes Mellitus (GDM) is a transient diabetogenic state that often leads to adverse maternal and fetal outcomes. The rising burden of exposure to endocrine-disrupting chemicals like phthalates essentially disrupts the tightly regulated endocrine system, thereby modulating the insulin signaling pathways, leading to GDM.

Objective

In the present work, a systematic review was performed to examine the probable relation between maternal exposure to phthalates, as endocrine-disrupting compounds, and GDM.

Methods

Relevant studies from their inception to April 2025 were identified by searching PubMed, Embase, Scopus, and Science Direct. The data were screened using the Rayyan tool, and the risk of bias was assessed using the New Castle Ottawa Scale se

SUBMITTER: Mitra T 

PROVIDER: S-EPMC12497590 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature