Unveiling the neutrophil-Notch2-ISC axis: asiatic acid's therapeutic strategy in infectious colitis.

ABSTRACT:

Introduction

Salmonella-induced colitis is a global health burden characterized by intestinal barrier disruption and deficient epithelial repair that involves a critical interplay between neutrophil dynamics and intestinal stem cell (ISC) regeneration. Current therapies do not target this interplay and do not adequately address therapeutic need. This study investigated the therapeutic mechanism of asiatic acid (AA) in a murine Salmonella typhimurium (S.T) infection model, focusing on its effects on the neutrophil-Notch-ISC axis.

Methods

Balb/c mice were administered S.T for 3 days to model S.T infection AA (10 mg/kg) was gavage administered to mice 6 h after the S.T infection. Neutrophil-deficient mice were generated by daily intrape

SUBMITTER: Zou W 

PROVIDER: S-EPMC12497614 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature